In addition to extending their previous research on the mechanisms of action of these botanical products in the brain, this Center will also seek to understand the role of the human gastrointestinal microflora microbiome in their activity, and in cognitive and psychological health more generally.
Botanical Interaction Studies Principal Investigator: Missouri Botanical Garden, St. Wake Forest University Center website: University of California, Santa Cruz Center website: To improve the speed, breadth, and precision of the chemical and biological characterization of natural products, the team will develop innovative, cell-based screening approaches to uncover bioactive molecules of interest and their corresponding molecular targets.
Purdue University, West Lafayette, IN; Rutgers, The State University of New Jersey, New Brunswick; University of North Texas, Denton This new Center will focus on the mechanisms through which polyphenol-containing dietary supplements derived from grapes promote cognitive and psychological resilience to common psychological stresses including sleep deprivation.
Previously, the team focused on the safety of commonly used dietary supplements such as black cohosh, hops, and licorice, and their effects on estrogenic hormones. A vital component of this Center will be the dissemination of primary data to the greater scientific community through a searchable, data-driven website.
These activities will be pursued in coordination with the above-mentioned Center for High-throughput Functional Annotation of Natural Products. The center will study different populations to determine where botanical lipids are most likely to be effective. In the next award period the team will advance its ground-breaking work on the characterization and standardization of complex botanical products, and on the interactions of those products with estrogens and with prescription drugs, with a continuing focus on safety.
Atheroprotective Mechanisms of Borage and Echium Oils Mechanisms of Actions of Botanical Lipids on Effector Cells of Asthma Role of Fatty Acid Desaturase Polymorphisms in Determining the Effectiveness of PUFA-based Botanical Supplements in Humans The goal of this center in its second 5-year cycle is to delineate the molecular mechanisms by which botanical oils prevent or impact disease cardiovascular disease, asthma and metabolic syndrome with a particular focus on immunity and inflammation.
The projects look at molecular mechanisms and cellular pathways of botanical estrogens and their actions on bone, uterus, mammary tissue, breast cancer metastasis, and cognition.
This Center will also explore the role of the gastrointestinal microbiome in the biological effects of the products studied, which will include bitter melon and fenugreek. This center will also pioneer the application of cutting-edge bioanalytical methodologies to botanicals, develop innovative approaches to the holistic characterization of the metabolomic complexity of natural products, and share all of these efforts with the relevant research communities.
University of Illinois at Chicago Center website: Botanicals and Metabolic Resiliency Principal Investigator:Nov 17, · Abstracts of consumer research studies conducted or supported by the Center for Food Safety and Applied Nutrition The implications of generally different motivations for dietary supplement use.
The Office of Dietary Supplements (ODS) initiated the Centers for Advancing Research on Botanical and Other Natural Products (CARBON) Program in partnership with the National Center for Complementary and Integrative Health (NCCIH) inin response to a Congressional mandate.
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